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Glycan Analysis and Influenza A Virus Infection of Primary Swine Respiratory Epithelial Cells

20 Aug 2010

Abstract excerpt

To better understand influenza virus infection of pigs, we examined primary swine respiratory epithelial cells (SRECs, the primary target cells of influenza viruses in vivo), as a model system. Glycomic profiling of SRECs by mass spectrometry revealed a diverse range of glycans terminating in sialic acid or GalαGal. In terms of sialylation, α2-6 linkage was more abundant than α2-3, and NeuAc was more abundant...

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PMID: 20724471
DOI: 10.1074/jbc.m110.115998

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