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Atypical expression and distribution of embryonic stem cell marker, OCT4, in human lung adenocarcinoma

18 Aug 2010

Abstract excerpt

BACKGROUND AND OBJECTIVES: Lung cancer is one of the leading causes of cancer-related deaths in the world. Although the origin still remains to be resolved, a prevailing hypothesis implies the involvement of cancer stem cells (CSCs) responsible for tumor initiation, maintenance, and progression. Embryonic stem cell marker, OCT4, encoding the spliced variants OCT4A and OCT4B, has recently been shown to have a dual...

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PMID: 20721963
DOI: 10.1002/jso.21665

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