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Structure of Hepatitis E Virion-sized Particle Reveals an RNA-dependent Viral Assembly Pathway*

19 Aug 2010

Abstract excerpt

Hepatitis E virus (HEV) induces acute hepatitis in humans with a high fatality rate in pregnant women. There is a need for anti-HEV research to understand the assembly process of HEV native capsid. Here, we produced a large virion-sized and a small T=1 capsid by expressing the HEV capsid protein in insect cells with and without the N-terminal 111 residues, respectively, for comparative structural analysis. The...

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PMID: 20720013
DOI: 10.1074/jbc.m110.106336

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