Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study.

Cardiovascular diabetology - 18 Aug 2010

Ley Sylvia H, Hegele Robert A, Connelly Philip W, Harris Stewart B, Mamakeesick Mary, Cao Henian, Gittelsohn Joel, Retnakaran Ravi, Zinman Bernard, Hanley Anthony J

Abstract excerpt

BACKGROUND: C-reactive protein (CRP), a biomarker of inflammation, has been associated with increased risk of developing cardiovascular disease. Common variants of the hepatocyte nuclear factor 1A (HNF1A) gene encoding HNF-1alpha have been associated with plasma CRP in predominantly European Caucasian samples. HNF1A might therefore have an impact on vascular disease and diabetes risk that is mediated by CRP. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to C-Reactive Protein
Share to Canada

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular Diseases

Share to Diabetes Mellitus, Type 2

Share to Hepatocyte Nuclear Factor 1-alpha

Share to Indians, North American

Share to Inflammation

Share to Prevalence

Source

Open in PubMed Open full text

Identifiers

PMID: 20716378
DOI: 10.1186/1475-2840-9-39
PMCID: PMC2929219

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study.PMID 20716378Read ↗

The hepatic nuclear factor-1alpha G319S variant is associated with early-onset type 2 diabetes in Canadian Oji-Cree.Semantic proximity Read ↗

Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.Semantic proximity Read ↗

Clinical utility of HNF1A genotyping for diabetes in aboriginal Canadians.Semantic proximity Read ↗

The prevalence of the HNF-1alpha G319S mutation in Canadian aboriginal youth with type 2 diabetes.Semantic proximity Read ↗

Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey.Semantic proximity Read ↗

Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.Semantic proximity Read ↗

Common coding variants of the HNF1A gene are associated with multiple cardiovascular risk phenotypes in community-based samples of younger and older European-American adults: the Coronary Artery Risk Development in Young Adults Study and The Cardiovascular Health Study.Semantic proximity Read ↗

Peroxisome proliferator-activated receptor-gamma2 P12A and type 2 diabetes in Canadian Oji-Cree.Semantic proximity Read ↗

Genes, environment and Oji-Cree type 2 diabetes.Semantic proximity Read ↗

Pleiotropic effects of HNF1A rs1183910 in a population-based study of 60,283 individuals.Semantic proximity Read ↗

Hepatic nuclear factor 1-α: inflammation, genetics, and atherosclerosisSemantic proximity Read ↗

A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.