Article
Common coding variants of the HNF1A gene are associated with multiple cardiovascular risk phenotypes in community-based samples of younger and older European-American adults: the Coronary Artery Risk Development in Young Adults Study and The Cardiovascular Health Study.
Circulation. Cardiovascular genetics - 1 Jun 2009
Reiner Alexander P, Gross Myron D, Carlson Christopher S, Bielinski Suzette J, Lange Leslie A, Fornage Myriam, Jenny Nancy S, Walston Jeremy, Tracy Russell P, Williams O Dale, Jacobs David R, Nickerson Deborah A
Abstract excerpt
BACKGROUND: The transcription factor hepatocyte nuclear factor (HNF)-1 alpha regulates the activity of a number of genes involved in innate immunity, blood coagulation, lipid and glucose transport and metabolism, and cellular detoxification. Common polymorphisms of the HNF-1 alpha gene (HNF1A) we...
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