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Article

The enemy within: an epigenetic role of retrotransposons in cancer initiation.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Oct 2010

Wilkins Adam S

Abstract excerpt

This article proposes that cancers can be initiated by retrotransposon (RTN) activation through changes in the transcriptional regulation of nearby genes. I first detail the hypothesis and then discuss the nature of physiological stress(es) in RTN activation; the role of DNA demethylation in the initiation and propagation of new RTN states; the connection between ageing and cancer incidence and the involvement of...

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Identifiers

PMID: 20715060
DOI: 10.1002/bies.201000008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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