Article
AmrZ beta-sheet residues are essential for DNA binding and transcriptional control of Pseudomonas aeruginosa virulence genes.
Journal of bacteriology - 1 Oct 2010
Waligora Elizabeth A, Ramsey Deborah M, Pryor Edward E, Lu Haiping, Hollis Thomas, Sloan Gina P, Deora Rajendar, Wozniak Daniel J
Abstract excerpt
AmrZ is a putative ribbon-helix-helix (RHH) transcriptional regulator. RHH proteins utilize residues within the β-sheet for DNA binding, while the α-helices promote oligomerization. AmrZ is of interest due to its dual roles as a transcriptional activator and as a repressor, regulating genes encoding virulence factors associated with both chronic and acute Pseudomonas aeruginosa infection. In this study,...
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