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Article

Genetic validation of whole-transcriptome sequencing for mapping expression affected by cis-regulatory variation.

BMC genomics - 13 Aug 2010

Babak Tomas, Garrett-Engele Philip, Armour Christopher D, Raymond Christopher K, Keller Mark P, Chen Ronghua, Rohl Carol A, Johnson Jason M, Attie Alan D, Fraser Hunter B, Schadt Eric E

Abstract excerpt

BACKGROUND: Identifying associations between genotypes and gene expression levels using microarrays has enabled systematic interrogation of regulatory variation underlying complex phenotypes. This approach has vast potential for functional characterization of disease states, but its prohibitive cost, given hundreds to thousands of individual samples from populations have to be genotyped and expression profiled,...

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Identifiers

PMID: 20707912
DOI: 10.1186/1471-2164-11-473
PMCID: PMC3091669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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