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Manipulation of Autophagy in Cancer Cells: An Innovative Strategy to Fight Drug Resistance

1 Jun 2013

Abstract excerpt

Autophagy is a catabolic process activated by stress conditions and nutrient deprivation, to which it reacts by promoting the degradation of damaged organelles and misfolded/aggregated proteins, as well as generating new energetic pools. Paradoxically, in cancer cells, which signal the dangerous microenvironment occurring during clinical therapies, autophagy could promote their proliferation and sustain drug...

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PMID: 23734684
DOI: 10.4155/fmc.13.85

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