Article
Adiponectin deficiency promotes tumor growth in mice by reducing macrophage infiltration.
PloS one - 5 Aug 2010
Sun Yutong, Lodish Harvey F
Abstract excerpt
Adiponectin is an adipocyte-derived plasma protein that has been implicated in regulating angiogenesis, but the role of adiponectin in regulating this process is still controversial. In this study, in order to determine whether adiponectin affects tumor growth and tumor induced vascularization, we implanted B16F10 melanoma and Lewis Lung Carcinoma cells subcutaneously into adiponectin knockout and wild-type...
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