Disease-specific, neurosphere-derived cells as models for brain disorders.

doi:10.1242/dmm.005447

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Disease-specific, neurosphere-derived cells as models for brain disorders.

Disease models & mechanisms - 1 Jan 2000

Matigian Nicholas, Abrahamsen Greger, Sutharsan Ratneswary, Cook Anthony L, Vitale Alejandra M, Nouwens Amanda, Bellette Bernadette, An Jiyuan, Anderson Matthew, Beckhouse Anthony G, Bennebroek Maikel, Cecil Rowena, Chalk Alistair M, Cochrane Julie, Fan Yongjun, Féron François, McCurdy Richard, McGrath John J, Murrell Wayne, Perry Chris, Raju Jyothy, Ravishankar Sugandha, Silburn Peter A, Sutherland Greg T, Mahler Stephen, Mellick George D, Wood Stephen A, Sue Carolyn M, Wells Christine A, Mackay-Sim Alan

Abstract excerpt

There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses. We describe here a new cell model based on patient-derived cells from the human olfactory mucosa,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Shape

Share to Immunophenotyping

Share to Metabolic Networks and Pathways

Share to Olfactory Mucosa

Share to Oligonucleotide Array Sequence Analysis

Share to Parkinson Disease

Share to Schizophrenia

Source

Open in PubMed

Identifiers

PMID: 20699480
DOI: 10.1242/dmm.005447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20699480-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disease-specific, neurosphere-derived cells as models for brain disorders.PMID 20699480Read ↗

Cultured Mesenchymal Cells from Nasal Turbinate as a Cellular Model of the Neurodevelopmental Component of Schizophrenia EtiologySemantic proximity Read ↗

Disease signatures for schizophrenia and bipolar disorder using patient-derived induced pluripotent stem cells.Semantic proximity Read ↗

Olfactory neuroepithelium-derived neural progenitor cells as a model system for investigating the molecular mechanisms of neuropsychiatric disorders.Semantic proximity Read ↗

Human olfactory neuronal cells through nasal biopsy: molecular characterization and utility in brain scienceSemantic proximity Read ↗

BRN2 and PTN unveil multiple neurodevelopmental mechanisms in Schizophrenia patient-derived cerebral organoidsSemantic proximity Read ↗

Ventral forebrain organoids derived from individuals with schizophrenia recapitulate perturbed striatal gene expression dynamics of the donor’s brainsSemantic proximity Read ↗

Differences between Cerebral Organoids Derived from a non-PD and a Parkinson’s Patient: A Potential Vulnerability for Neuroinvasive VirusesSemantic proximity Read ↗

Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression.Semantic proximity Read ↗

Comparison of Model Systems for Emulating Human Tissue and Physiology in Psychiatric ResearchSemantic proximity Read ↗

The Proteomic Architecture of Schizophrenia Cerebral Organoids Reveals Alterations in GWAS and Neuronal Development FactorsSemantic proximity Read ↗

Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids.Semantic proximity Read ↗

Hallmark molecular and pathological features of POLG disease are recapitulated in cerebral organoidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.