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Article

Mutant human FUS Is ubiquitously mislocalized and generates persistent stress granules in primary cultured transgenic zebrafish cells.

PloS one - 1 Jan 2014

Acosta Jamie Rae, Goldsbury Claire, Winnick Claire, Badrock Andrew P, Fraser Stuart T, Laird Angela S, Hall Thomas E, Don Emily K, Fifita Jennifer A, Blair Ian P, Nicholson Garth A, Cole Nicholas J

Abstract excerpt

FUS mutations can occur in familial amyotrophic lateral sclerosis (fALS), a neurodegenerative disease with cytoplasmic FUS inclusion bodies in motor neurons. To investigate FUS pathology, we generated transgenic zebrafish expressing GFP-tagged wild-type or fALS (R521C) human FUS. Cell cultures were made from these zebrafish and the subcellular localization of human FUS and the generation of stress granule (SG)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24912067
DOI: 10.1371/journal.pone.0090572
PMCID: PMC4049593

Genes

FUS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Mutant human FUS Is ubiquitously mislocalized and generates persistent stress granules in primary cultured transgenic zebrafish cells.PMID 24912067Read ↗

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