Article
Haptoglobin synergistically potentiates bradykinin and thrombin induced prostaglandin biosynthesis in isolated osteoblasts.
Biochemical and biophysical research communications - 15 Jul 1991
Fröhlander N, Ljunggren O, Lerner U H
Abstract excerpt
Haptoglobin of two different phenotypes (Hp 1-1 and Hp 2-1) dose-dependently (1-4 mg/ml) stimulated the formation of prostaglandin E2 (PGE2) in osteoblast-like cells isolated from neonatal mouse calvarial bones. The degree of stimulation obtained by haptoglobins (4 mg/ml) on PGE2 biosynthesis was in the same range as that caused by bradykinin (1 mumol/l). Pretreatment of osteoblasts with Hp 1-1 or Hp 2-1 (1-4...
Topics
- Animals
- Bradykinin
- Cells, Cultured
- Dinoprostone
- Drug Synergism
- Haptoglobins
- Humans
- Kinetics
- Mice
- Osteoblasts
- Phenotype
- Prostaglandins