Article
Association to the Glypican-5 gene in multiple sclerosis.
Journal of neuroimmunology - 14 Sept 2010
Lorentzen Aslaug R, Melum Espen, Ellinghaus Eva, Smestad Cathrine, Mero Inger-Lise, Aarseth Jan H, Myhr Kjell-Morten, Celius Elisabeth G, Lie Benedicte A, Karlsen Tom H, Franke Andre, Harbo Hanne F
Abstract excerpt
Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we genotyped 33 SNPs in 1355 Norwegian MS patients and 1446 Norwegian controls. An intronic SNP in the...
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