Article
ADP/ATP mitochondrial carrier MD simulations to shed light on the structural-dynamical events that, after an additional mutation, restore the function in a pathological single mutant.
Journal of structural biology - 1 Dec 2010
Di Marino Daniele, Oteri Francesco, Morozzo Della Rocca Blasco, Chillemi Giovanni, Falconi Mattia
Abstract excerpt
Molecular dynamics simulations of the wild type bovine ADP/ATP mitochondrial carrier, and of the single Ala113Pro and double Ala113Pro/Val180Met mutants, embedded in a lipid bilayer, have been carried out for 30ns to shed light on the structural-dynamical changes induced by the Val180Met mutation restoring the carrier function in the Ala113Pro pathologic mutant. Principal component analysis indicates that, for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.