Article
Increased sensitivity of histidinemic mice to UVB radiation suggests a crucial role of endogenous urocanic acid in photoprotection.
The Journal of investigative dermatology - 1 Jan 2011
Barresi Caterina, Stremnitzer Caroline, Mlitz Veronika, Kezic Sanja, Kammeyer Arthur, Ghannadan Minoo, Posa-Markaryan Katja, Selden Clare, Tschachler Erwin, Eckhart Leopold
Abstract excerpt
Urocanic acid (UCA) is produced by the enzyme histidase and accumulates in the stratum corneum of the epidermis. In this study, we investigated the photoprotective role of endogenous UCA in the murine skin using histidinemic mice, in which the gene encoding histidase is mutated. Histidase was detected by immunohistochemistry in the stratum granulosum and stratum corneum of the normal murine skin but not in the...
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