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Article

Residues in a highly conserved claudin-1 motif are required for hepatitis C virus entry and mediate the formation of cell-cell contacts.

Journal of virology - 1 Jun 2009

Cukierman Lisa, Meertens Laurent, Bertaux Claire, Kajumo Francis, Dragic Tatjana

Abstract excerpt

Claudin-1, a component of tight junctions between liver hepatocytes, is a hepatitis C virus (HCV) late-stage entry cofactor. To investigate the structural and functional roles of various claudin-1 domains in HCV entry, we applied a mutagenesis strategy. Putative functional intracellular claudin-1 domains were not important. However, we identified seven novel residues in the first extracellular loop that are...

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Identifiers

PMID: 19297469
DOI: 10.1128/JVI.02262-08
PMCID: PMC2681980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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