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Combined effect of CYP1B1 codon 432 polymorphism and N-acetyltransferase 2 slow acetylator phenotypes in relation to breast cancer in the Turkish population.

Anticancer research - 1 Jul 2010

Ozbek Yasemin K, Oztürk Tülin, Tüzüner Bora M, Calay Zerrin, Ilvan Sennur, Seyhan Fatih M, Kisakesen Halil I, Oztürk Oguz, Isbir Turgay

Abstract excerpt

BACKGROUND: Breast cancer (BC), is more prevalent in subjects who have had prolonged exposure to heterocyclic amines, aromatic amines and high levels of oestradiol. Cytochrome P450 1B1 (CYP1B1) and N-acetyltransferase2 (NAT2) have complementary role in metabolism of xenobiotics such as arylamines and heterocyclic amines, CYP1B1 also hyroxylates 17-beta oestradiol. CYP1B1*3 polymorphism and seven missense and four...

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Share to Aryl Hydrocarbon Hydroxylases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20683028

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NAT2

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