Article
Morphology, size distribution, and aggregate structure of lipopolysaccharide and lipid A dispersions from enterobacterial origin.
Innate immunity - 1 Oct 2011
Richter Walter, Vogel Vitali, Howe Jörg, Steiniger Frank, Brauser Annemarie, Koch Michel Hj, Roessle Manfred, Gutsmann Thomas, Garidel Patrick, Mäntele Werner, Brandenburg Klaus
Abstract excerpt
Lipopolysaccharides (LPSs) from Gram-negative bacteria are strong elicitors of the human immune systems. There is strong evidence that aggregates and not monomers of LPS play a decisive role at least in the initial stages of cell activation of immune cells such as mononuclear cells. In previous reports, it was shown that the biologically most active part of enterobacterial LPS, hexa-acyl bisphosphorylated lipid...
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