Article
Understanding the population structure of North American patients with cystic fibrosis.
Clinical genetics - 1 Feb 2011
Li W, Sun L, Corey M, Zou F, Lee S, Cojocaru A L, Taylor C, Blackman S M, Stephenson A, Sandford A J, Dorfman R, Drumm M L, Cutting G R, Knowles M R, Durie P, Wright F A, Strug L J
Abstract excerpt
It is generally presumed that the cystic fibrosis (CF) population is relatively homogeneous, and predominantly of European origin. The complex ethnic make-up observed in the CF patients collected by the North American CF Modifier Gene Consortium has brought this assumption into question, and suggested the potential for population substructure in the three CF study samples collected from North America. It is well...
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