Article
Self-reported ethnicity, genetic structure and the impact of population stratification in a multiethnic study.
Human genetics - 1 Aug 2010
Wang Hansong, Haiman Christopher A, Kolonel Laurence N, Henderson Brian E, Wilkens Lynne R, Le Marchand Loïc, Stram Daniel O
Abstract excerpt
It is well-known that population substructure may lead to confounding in case-control association studies. Here, we examined genetic structure in a large racially and ethnically diverse sample consisting of five ethnic groups of the Multiethnic Cohort study (African Americans, Japanese Americans, Latinos, European Americans and Native Hawaiians) using 2,509 SNPs distributed across the genome. Principal component...
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