Article
Hypermutability of CpG dinucleotides in the propeptide-encoding sequence of the human albumin gene.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990
Brennan S O, Arai K, Madison J, Laurell C B, Galliano M, Watkins S, Peach R, Myles T, George P, Putnam F W
Abstract excerpt
An electrophoretically slow albumin variant was detected with a phenotype frequency of about 1:1000 in Sweden and was also found in a family of Scottish descent from Kaikoura, New Zealand, and in five families in Tradate, Italy. Structural study established that the major variant component was arginyl-albumin, in which arginine at the -1 position of the propeptide is still attached to the processed albumin. A...
Topics
- Amino Acid Sequence
- DNA
- Dinucleoside Phosphates
- Genes
- Genetic Variation
- Humans
- Molecular Sequence Data
- Mutation
- Phenotype
- Polymerase Chain Reaction
- Prealbumin