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Article

Batch effects in the BRLMM genotype calling algorithm influence GWAS results for the Affymetrix 500K array.

The pharmacogenomics journal - 1 Aug 2010

Miclaus K, Wolfinger R, Vega S, Chierici M, Furlanello C, Lambert C, Hong H, Zhang Li, Yin S, Goodsaid F

Abstract excerpt

The Affymetrix GeneChip Human Mapping 500K array is common for genome-wide association studies (GWASs). Recent findings highlight the importance of accurate genotype calling algorithms to reduce the inflation in Type I and Type II error rates. Differential results due to genotype calling errors can introduce severe bias in case-control association study results. Using data from the Wellcome Trust Case Control...

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PMID: 20676071
DOI: 10.1038/tpj.2010.36

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CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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