Article
Clinically significant CYP2C inhibition by noscapine but not by glucosamine.
Clinical pharmacology and therapeutics - 1 Sept 2010
Rosenborg S, Stenberg M, Otto S, Ostervall J, Masquelier M, Yue Q-Y, Bertilsson L, Eliasson E
Abstract excerpt
Noscapine and glucosamine reportedly interact with warfarin. We investigated the effects of these drugs on various cytochrome P450 (CYP) activity markers. Twelve healthy subjects were phenotyped at baseline and during separate treatments with noscapine and glucosamine. Whereas glucosamine had no significant effect on CYP activity, noscapine caused marked inhibition of CYP2C9 (4.9-fold increase in urinary...
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