Article
T-cell phenotype in protocol renal biopsy from transplant recipients treated with belatacept-mediated co-stimulatory blockade.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 2011
Grimbert Philippe, Audard Vincent, Diet Carine, Matignon Marie, Plonquet Anne, Mansour Hicham, Desvaux Dominique, Durrbach Antoine, Cohen José Laurent, Lang Philippe
Abstract excerpt
BACKGROUND: Belatacept is thought to disrupt the interaction between CD80/86 and CD28, thus preventing T-cell activation by blocking the co-stimulatory second signal. However, the consequences on the T-cell profile in human renal transplant cases have not been determined. METHODS: In this study,...
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