Article
DNA diagnosis of hydatidiform mole using the polymerase chain reaction.
Human genetics - 1 Jun 1991
Fukuyama R, Takata M, Kudoh J, Sakai K, Tamura S, Shimizu N
Abstract excerpt
We have used the polymerase chain reaction (PCR) technique for the diagnosis of hydatidiform mole, a trophoblastic disease. For this, we targeted the hypervariable 3' flanking region of the APOB gene (APOB/VNTR) because of its high heterozygosity index (0.61) in the Japanese population. We examined seven clinical cases which were tentatively diagnosed as hydatidiform moles. Five of these revealed DNA segments...
Topics
- Alleles
- Base Sequence
- Electrophoresis, Polyacrylamide Gel
- Female
- Humans
- Hydatidiform Mole
- Molecular Sequence Data
- Polymerase Chain Reaction
- Pregnancy
- Uterine Neoplasms