Article
Cell cycle-specific expression of the SWI4 transcription factor is required for the cell cycle regulation of HO transcription.
Genes & development - 1 Jul 1991
Breeden L, Mikesell G E
Abstract excerpt
Expression of the HO endonuclease triggers mating-type switching in Saccharomyces cerevisiae. Transcription of the HO gene is start-dependent and restricted to the late G1/early S phase of haploid mother cells. The HO promoter contains 10 copies of a cell cycle-regulated upstream activation sequence, which is activated by SWI4 and SWI6. SWI4 mRNA levels vary at least 10-fold throughout the cell cycle and rise...
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