Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recurrent EML4-ALK-associated lung adenocarcinoma with a slow clinical course.

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2010

Murakami Shuji, Yokose Tomoyuki, Saito Haruhiro, Sakuma Yuji, Matsukuma Shoichi, Hasegawa Chikako, Kondo Tetsuro, Oshita Fumihiro, Ito Hiroyuki, Tsuboi Masahiro, Nakayama Haruhiko, Kameda Youichi, Noda Kazumasa, Yamada Kouzo

Abstract excerpt

The fusion gene EML4-ALK (echinoderm microtubule-associated protein-like 4 gene and the anaplastic lymphoma kinase gene) was recently identified as a novel genetic alteration in non-small-cell lung cancer. The clinicopathological features of EML4-ALK-positive adenocarcinoma are reported to include its high incidence in young, non-smoking patients, tumors that show distinct solid or acinar growth patterns with or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Diagnosis, Differential

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Recurrence, Local

Share to Oncogene Proteins, Fusion

Share to Pleural Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

Share to ras Proteins

Share to Tomography, X-Ray Computed

Source

Identifiers

PMID: 20659620
DOI: 10.1016/j.lungcan.2010.05.019

Genes

ALK
EML4
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recurrent EML4-ALK-associated lung adenocarcinoma with a slow clinical course.PMID 20659620Read ↗

The biology and treatment of EML4-ALK non-small cell lung cancer.Semantic proximity Read ↗

A case of lung adenocarcinoma harboring EGFR mutation and EML4-ALK fusion gene.Semantic proximity Read ↗

A case of lung adenocarcinoma with a concurrent EGFR mutation and ALK rearrangement: A case report and literature review.Semantic proximity Read ↗

Non-small cell lung cancer with EML4-ALKtranslocation in Chinese male never-smokers is characterized with early-onsetSemantic proximity Read ↗

An extremely rare case of small-cell lung cancer harboring variant 2 of the EML4-ALK fusion gene.Semantic proximity Read ↗

EML4-ALK rearrangement and its clinical significance in Chinese patients with advanced non-small cell lung cancer.Semantic proximity Read ↗

EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.Semantic proximity Read ↗

Lung adenocarcinoma with concurrent KRAS mutation and ALK rearrangement responding to crizotinib: case report.Semantic proximity Read ↗

Second Primary Lung Adenocarcinoma Harboring EML4-ALK After Surgically Resected EGFR Positive Lung Adenocarcinoma.Semantic proximity Read ↗

Activity of EGFR-tyrosine kinase and ALK inhibitors for EML4-ALK-rearranged non-small-cell lung cancer harbored coexisting EGFR mutation.Semantic proximity Read ↗

Comparison of clinical characteristics between patients with ALK-positive and EGFR-positive lung adenocarcinoma.Semantic proximity Read ↗

Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.