Article
Low template STR typing: effect of replicate number and consensus method on genotyping reliability and DNA database search results.
Forensic science international. Genetics - 1 Aug 2011
Benschop Corina C G, van der Beek Cornelis P, Meiland Hugo C, van Gorp Ankie G M, Westen Antoinette A, Sijen Titia
Abstract excerpt
To analyze DNA samples with very low DNA concentrations, various methods have been developed that sensitize short tandem repeat (STR) typing. Sensitized DNA typing is accompanied by stochastic amplification effects, such as allele drop-outs and drop-ins. Therefore low template (LT) DNA profiles are interpreted with care. One can either try to infer the genotype by a consensus method that uses alleles confirmed in...
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