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Article

Toll-like receptors, tumor necrosis factor-α, and interleukin-10 gene polymorphisms in risk of pulmonary tuberculosis and disease severity.

Human immunology - 1 Oct 2010

Ma Mai-juan, Xie Lan-pin, Wu Shu-cai, Tang Fang, Li Hao, Zhang Zheng-shan, Yang Hong, Chen Su-li, Liu Ning, Liu Wei, Cao Wu-chun

Abstract excerpt

Toll-like receptors (TLRs) and cytokines play key roles in innate and adaptive immunity against Mycobacterium tuberculosis (M.TB). The aim of this study was to investigate whether the functional genetic variations at position 1805 G/T in TLR1, 2258 A/G in TLR2, -857 C/T, and -863 A/C in tumor necrosis factor-α (TNF-α), as well as -819 C/T in interleukin-10 (IL-10) confer susceptibility to pulmonary tuberculosis...

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Source

Identifiers

PMID: 20650298
DOI: 10.1016/j.humimm.2010.07.009

Genes

TNF
TLR1
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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