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Article

Tissue-specific regulatory regions of the PTH gene localized by novel chromosome 11 rearrangement breakpoints in a parathyroid adenoma.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2010

Mallya Sanjay M, Wu H Irene, Saria Elizabeth A, Corrado Kristin R, Arnold Andrew

Abstract excerpt

Parathyroid adenomas can contain clonal rearrangements of chromosome 11 that activate the cyclin D1 oncogene through juxtaposition with the PTH gene. Here we describe such a chromosomal rearrangement whose novel features provide clues to locating elusive cis-regulatory elements in the PTH gene and also expand the physical spectrum of pathogenetic breakpoints in the cyclin D1 gene region. Southern blot analyses of...

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Share to Chromosome Breakpoints
Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Regulatory Sequences, Nucleic Acid

Source

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Identifiers

PMID: 20641034
DOI: 10.1002/jbmr.187
PMCID: PMC3119366

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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