Article
A comparison of the caffeine halothane muscle contracture test with the molecular genetic diagnosis of malignant hyperthermia.
Anesthesiology - 1 Jul 1991
MacKenzie A E, Allen G, Lahey D, Crossan M L, Nolan K, Mettler G, Worton R G, MacLennan D H, Korneluk R
Abstract excerpt
Malignant hyperthermia (MH) is currently diagnosed by the caffeine-halothane contracture (CHC) test. In a previous study, this test was used to establish linkage between the human gene for MH susceptibility and the ryanodine receptor (RYR) gene. The current study extends the genetic linkage analysis to a large French-Canadian kindred. In this family, genetic linkage between RYR and MH genes was not demonstrable...
Topics
- Alleles
- Caffeine
- Child
- Female
- Genetic Linkage
- Genetic Markers
- Halothane
- Humans
- Male
- Malignant Hyperthermia
- Muscle Contraction