Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity

13 Jul 2010

Abstract excerpt

Glioblastoma (GBM) is the most aggressive primary brain tumor and is resistant to all therapeutic regimens. Relapse occurs regularly and might be caused by a poorly characterized tumor stem cell (TSC) subpopulation escaping therapy. We suggest aldehyde dehydrogenase 1 (ALDH1) as a novel stem cell marker in human GBM. Using the neurosphere formation assay as a functional method to identify brain TSCs, we show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism
Share to Glioma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20627895
DOI: 10.1093/neuonc/noq070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacityPMID 20627895Read ↗

CD133+ and CD133− Glioblastoma-Derived Cancer Stem Cells Show Differential Growth Characteristics and Molecular ProfilesSemantic proximity Read ↗

ALDH1 as a Functional Marker of Cancer Stem and Progenitor CellsSemantic proximity Read ↗

ALDH1L2 Knockout in U251 Glioblastoma Cells Reduces Tumor Sphere Formation by Increasing Oxidative Stress and Suppressing Methionine DependencySemantic proximity Read ↗

The ALDH1+ subpopulation of the human NMFH-1 cell line exhibits cancer stem-like characteristicsSemantic proximity Read ↗

Differentiation of glioblastoma multiforme stem-like cells leads to downregulation of EGFR and EGFRvIII and decreased tumorigenic and stem-like cell potentialSemantic proximity Read ↗

Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastomaSemantic proximity Read ↗

Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistanceSemantic proximity Read ↗

Isolation and Expansion of Human Glioblastoma Multiforme Tumor Cells Using the Neurosphere AssaySemantic proximity Read ↗

Curcumin-based-fluorescent probes targeting ALDH1A3 as a promising tool for glioblastoma precision surgery and early diagnosisSemantic proximity Read ↗

Aldehyde Dehydrogenase 1, a Potential Marker for Cancer Stem Cells in Human SarcomaSemantic proximity Read ↗

The Utility and Limitations of Neurosphere Assay, CD133 Immunophenotyping and Side Population Assay in Glioma Stem Cell ResearchSemantic proximity Read ↗

Human cortical glial tumors contain neural stem‐like cells expressing astroglial and neuronal markers in vitroSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.