Article
Using RB1 mutations to assess minimal residual disease in metastatic retinoblastoma.
Translational research : the journal of laboratory and clinical medicine - 1 Aug 2010
Dimaras Helen, Rushlow Diane, Halliday William, Doyle John J, Babyn Paul, Abella Esteban M, Williams James, Héon Elise, Gallie Brenda L, Chan Helen S L
Abstract excerpt
To assess complete remission before subjecting nongermline metastatic retinoblastoma patients to an autologous peripheral stem cell transplant, we tested for patient-specific retinoblastoma tumor suppressor gene (RB1) mutant alleles in cerebrospinal fluid (CSF) and bone marrow. In 1 child with CSF and 1 with bone marrow metastases, allele-specific polymerase chain reaction (AS-PCR) detected the biallelic RB1...
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