Article
Isolation of a fission yeast mutant that is sensitive to valproic acid and defective in the gene encoding Ric1, a putative component of Ypt/Rab-specific GEF for Ryh1 GTPase.
Molecular genetics and genomics : MGG - 1 Sept 2010
Ma Yan, Sugiura Reiko, Zhang Lili, Zhou Xin, Takeuchi Mai, He Yi, Kuno Takayoshi
Abstract excerpt
Valproic acid (VPA) causes various therapeutic and biological effects, but the exact mechanisms underlying these effects, however, remain elusive. To gain insights into the molecular mechanisms of VPA action, we performed in fission yeast a genetic screen for mutants that show VPA hypersensitivity and have identified several membrane-trafficking mutants including vas1-1/vps45 and vas2-1/aps1. Here, we describe...
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