Article
Single nucleotide polymorphism rs2229634 in the ITPR3 gene is associated with the risk of developing coronary artery aneurysm in children with Kawasaki disease.
International journal of immunogenetics - 1 Dec 2010
Huang Y-C, Lin Y-J, Chang J-S, Chen S-Y, Wan L, Sheu J J-C, Lai C-H, Lin C-W, Liu S-P, Chen C-P, Tsai F-J
Abstract excerpt
Kawasaki disease (KD) is the most common form of pediatric vasculitis. Though its etiology is unknown, researchers have suggested that it is related to genetics. The inositol 1,4,5-triphosphate receptor type 3 (ITPR3) gene has a strong association with the development of type 1 diabetes and, plays a critical role in the development of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis,...
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