Article
Association of COL11A2 polymorphism with susceptibility to Kawasaki disease and development of coronary artery lesions.
International journal of immunogenetics - 1 Dec 2010
Sheu J J, Lin Y J, Chang J S, Wan L, Chen S Y, Huang Y C, Chan C, Chiu I W, Tsai F J
Abstract excerpt
Kawasaki disease (KD) is a pediatric systemic vasculitis of unknown etiology wherein genetic influence is suspected. Gene clusters within the HLA region at chromosome 6p21.3 have been linked to KD and other autoimmune disorders. As collagen is a strong autoantigen inducing chronic inflammation in patients with vasculitis, this study tests a hypothesis that single-nucleotide polymorphism (SNP) of a collagen gene,...
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