Article
Genetic variation of DKK3 may modify renal disease severity in ADPKD.
Journal of the American Society of Nephrology : JASN - 1 Sept 2010
Liu Michelle, Shi Sally, Senthilnathan Sean, Yu Julie, Wu Elliot, Bergmann Carsten, Zerres Klaus, Bogdanova Nadja, Coto Eliecer, Deltas Constantinos, Pierides Alkis, Demetriou Kyproula, Devuyst Olivier, Gitomer Berenice, Laakso Marku, Lumiaho Anne, Lamnissou Klea, Magistroni Riccardo, Parfrey Patrick, Breuning Martijn, Peters Dorien J M, Torra Roser, Winearls Christopher G, Torres Vicente E, Harris Peter C, Paterson Andrew D, Pei York
Abstract excerpt
Significant variation in the course of autosomal dominant polycystic kidney disease ( ADPKD) within families suggests the presence of effect modifiers. Recent studies of the variation within families harboring PKD1 mutations indicate that genetic background may account for 32 to 42% of the variance in estimated GFR (eGFR) before ESRD and 43 to 78% of the variance in age at ESRD onset, but the genetic modifiers...
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