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Article

Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish.

Toxicology and applied pharmacology - 15 Aug 2017

Knecht Andrea L, Truong Lisa, Marvel Skylar W, Reif David M, Garcia Abraham, Lu Catherine, Simonich Michael T, Teeguarden Justin G, Tanguay Robert L

Abstract excerpt

Benzo[a]pyrene (B[a]P) is a well-known genotoxic polycylic aromatic compound whose toxicity is dependent on signaling via the aryl hydrocarbon receptor (AHR). It is unclear to what extent detrimental effects of B[a]P exposures might impact future generations and whether transgenerational effects might be AHR-dependent. This study examined the effects of developmental B[a]P exposure on 3 generations of zebrafish....

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Identifiers

PMID: 28583304
DOI: 10.1016/j.taap.2017.05.033
PMCID: PMC5539966

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AHR

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