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Article

Single nucleotide polymorphisms in the human Na+-dicarboxylate cotransporter affect transport activity and protein expression.

American journal of physiology. Renal physiology - 1 Oct 2010

Pajor Ana M, Sun Nina N

Abstract excerpt

The sodium-coupled transport of citric acid cycle intermediates in the intestine and kidney is mediated by the Na(+)-dicarboxylate cotransporter, NaDC1. In the kidney, NaDC1 plays an important role in regulating succinate and citrate concentrations in the urine, which may have physiological consequences including the development of kidney stones. In the present study, the impact of nonsynonymous single nucleotide...

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Identifiers

PMID: 20610529
DOI: 10.1152/ajprenal.00213.2010
PMCID: PMC2957249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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