Article
Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls.
International journal of urology : official journal of the Japanese Urological Association - 1 Apr 2007
Okamoto Naohiko, Aruga Seiji, Matsuzaki Shoji, Takahashi Satoru, Matsushita Kazuo, Kitamura Tadaichi
Abstract excerpt
PURPOSE: Urinary citrate is a potent inhibitor of renal stone formation. Its excretion is regulated by Na(+)/dicarboxylate cotransporter-1 (NaDC-1), which is expressed on the apical membrane of renal proximal tubules. Many patients with calcium urolithiasis exhibit hypocitraturia, however, the me...
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