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Article

Gain of local structure in an amphipathic peptide does not require a specific tertiary framework.

Proteins - 1 Oct 2010

Roman Ernesto A, Rosi Pablo, González Lebrero Mariano C, Wuilloud Rodolfo, González Flecha F Luis, Delfino José M, Santos Javier

Abstract excerpt

In this work, we studied how an amphipathic peptide of the surface of the globular protein thioredoxin, TRX94-108, acquires a native-like structure when it becomes involved in an apolar interaction network. We designed peptide variants where the tendency to form alpha-helical conformation is modulated by replacing each of the leucine amino acid residues by an alanine. The induction of structure caused by sodium...

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PMID: 20607854
DOI: 10.1002/prot.22789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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