Cloning of nocardioform DNA conferring the ability to inactivate rifampicin.

doi:10.1016/0378-1097(91)90093-p

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Article

Cloning of nocardioform DNA conferring the ability to inactivate rifampicin.

FEMS microbiology letters - 15 Apr 1991

Andersen S J, Dabbs E R

Abstract excerpt

A novel mechanism of resistance to rifampicin has recently been reported in which this antibiotic is inactivated. Here we describe the cloning of DNA from a nocardiofrom strain conferring this ability to inactivate rifampicin. Cloning was on the basis of complementation, as an increased resistanc...

Topics

Cloning, Molecular
DNA, Bacterial
Drug Resistance, Microbial
Escherichia coli
Mutation
Plasmids
Restriction Mapping
Rhodococcus
Rifampin
Transformation, Bacterial

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