Article
A FRET based melting curve analysis to detect nucleotide variations in HA receptor-binding site of H5N1 virus.
Molecular and cellular probes - 1 Oct 2010
De Santis R, Faggioni G, Ciammaruconi A, Fillo S, Clausi V, Corcioli F, Lista F, Azzi A
Abstract excerpt
Outbreaks of highly pathogenic H5N1 influenza A virus represent a major public health problem because of the possibility of direct transmission of these viruses from avian species to humans. For influenza H5N1 hemagglutinin, a switch from SA-a-2, 3-Gal to SA-a-2, 6-Gal receptor specificity is a critical step that could lead to inter-human transmission. The monitoring of the receptor-binding preference of H5N1...
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