Article
Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
Journal of neuroimmunology - 8 Oct 2010
Nischwitz Sandra, Cepok Sabine, Kroner Antje, Wolf Christiane, Knop Matthias, Müller-Sarnowski Felix, Pfister Hildegard, Roeske Darina, Rieckmann Peter, Hemmer Bernhard, Ising Marcus, Uhr Manfred, Bettecken Thomas, Holsboer Florian, Müller-Myhsok Bertram, Weber Frank
Abstract excerpt
In a genome wide association study consisting of 592 German multiple sclerosis (MS) patients and 825 controls we were able to replicate the association of the HLA region with MS independently of previous case control studies. No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene...
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