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Article

The effects of Di-(2-ethylhexyl)-phthalate exposure on fertilization and embryonic development in vitro and testicular genomic mutation in vivo.

PloS one - 1 Jan 2012

Huang Xue-Feng, Li Yan, Gu Yi-Hua, Liu Miao, Xu Yan, Yuan Yao, Sun Fei, Zhang Hui-Qin, Shi Hui-Juan

Abstract excerpt

The present study was undertaken to determine the reproductive hazards of Di-(2-ethylhexyl)-phthalate (DEHP) on mouse spermatozoa and embryos in vitro and genomic changes in vivo. Direct low-level DEHP exposure (1 μg/ml) on spermatozoa and embryos was investigated by in vitro fertilization (IVF) process, culture of preimplanted embryos in DEHP-supplemented medium and embryo transfer to achieve full term...

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Source

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Identifiers

PMID: 23226291
DOI: 10.1371/journal.pone.0050465
PMCID: PMC3511574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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