Article
Large-scale forward genetic screening analysis of development of hematopoiesis in zebrafish.
Journal of genetics and genomics = Yi chuan xue bao - 20 Sept 2012
Wang Kun, Huang Zhibin, Zhao Lingfeng, Liu Wei, Chen Xiaohui, Meng Ping, Lin Qing, Chi Yali, Xu Mengchang, Ma Ning, Zhang Yiyue, Zhang Wenqing
Abstract excerpt
Zebrafish is a powerful model for the investigation of hematopoiesis. In order to isolate novel mutants with hematopoietic defects, large-scale mutagenesis screening of zebrafish was performed. By scoring specific hematopoietic markers, 52 mutants were identified and then classified into four types based on specific phenotypic traits. Each mutant represented a putative mutation of a gene regulating the relevant...
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