Article
P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice.
Drug metabolism letters - 1 Dec 2010
Tagen Michael, Zhuang Yanli, Zhang Fan, Harstead K Elaine, Shen Jun, Schaiquevich Paula, Fraga Charles H, Panetta John C, Waters Christopher M, Stewart Clinton F
Abstract excerpt
The ATP-binding cassette transporters P-glycoprotein (ABCB1, MDR1) and multidrug resistance protein 4 (MRP4) efflux irinotecan and its active metabolite SN-38 in vitro, and thus may contribute to system clearance of these compounds. Mdr1a/b(-/-), Mrp4(-/-), and wild-type mice were administered 20 or 40 mg/kg irinotecan, and plasma samples were collected for 6 hours. Irinotecan and SN-38 lactone and carboxylate...
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