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Article

HIV-associated nephropathy: role of mammalian target of rapamycin pathway.

The American journal of pathology - 1 Aug 2010

Kumar Dileep, Konkimalla Sridevi, Yadav Anju, Sataranatarajan Kavithalakshmi, Kasinath Balakuntalam S, Chander Praveen N, Singhal Pravin C

Abstract excerpt

Both glomerular and tubular lesions are characterized by a proliferative phenotype in HIV-associated nephropathy. We hypothesized that mammalian target of rapamycin (mTOR) contributes to the development of the HIVAN phenotype. Both glomerular and tubular epithelial cells showed enhanced expression of phospho (p)-mTOR in HIV-1 transgenic mice (Tgs). In addition, renal tissues of transgenic mice (RT-Tg) showed...

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Identifiers

PMID: 20581056
DOI: 10.2353/ajpath.2010.100131
PMCID: PMC2913356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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