Article
APC mutations are associated with increased bone mineral density in patients with familial adenomatous polyposis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2010
Miclea Razvan L, Karperien Marcel, Langers Alexandra M, Robanus-Maandag Els C, van Lierop Antoon, van der Hiel Bernies, Stokkel Marcel P, Ballieux Bart E, Oostdijk Wilma, Wit Jan M, Vasen Hans F, Hamdy Neveen A
Abstract excerpt
The canonical Wnt pathway plays a key regulatory role in osteoblastogenesis and bone mass acquisition through its main effector, β-catenin. Adenomatous polyposis coli (APC) represents the key intracellular gatekeeper of β-catenin turnover, and heterozygous germ-line mutations in the APC gene caus...
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